Increased testosterone effects

Effect of testosterone on muscle mass and muscle protein synthesis

We have studied the effect of a pharmacological dose of testosterone enanthate (3 mg.kg-1.wk-1 for 12 wk) on muscle mass and total-body potassium and on whole-body and muscle protein synthesis in normal male subjects. Muscle mass estimated by creatinine excretion increased in all nine subjects (20% mean increase, P less than 0.02); total body potassium mass estimated by 40K counting increased in all subjects (12% mean increase, P less than 0.0001). In four subjects, a primed continuous infusion protocol with L-[1-13C]leucine was used to determine whole-body leucine flux and oxidation. Whole-body protein synthesis was estimated from nonoxidative flux. Muscle protein synthesis rate was determined by measuring [13C]leucine incorporation into muscle samples obtained by needle biopsy. Testosterone increased muscle protein synthesis in all subjects (27% mean increase, P less than 0.05). Leucine oxidation decreased slightly (17% mean decrease, P less than 0.01), but whole-body protein synthesis did not change significantly. Muscle morphometry showed no significant increase in muscle fiber diameter. These studies suggest that testosterone increases muscle mass by increasing muscle protein synthesis.

Similar articles

Griggs RC, Halliday D, Kingston W, Moxley RT 3rd. Griggs RC, et al. Ann Neurol. 1986 Nov;20(5):590-6. doi: 10.1002/ana.410200506. Ann Neurol. 1986. PMID: 2431651

Brodsky IG, Balagopal P, Nair KS. Brodsky IG, et al. J Clin Endocrinol Metab. 1996 Oct;81(10):3469-75. doi: 10.1210/jcem.81.10.8855787. J Clin Endocrinol Metab. 1996. PMID: 8855787

Young NR, Baker HW, Liu G, Seeman E. Young NR, et al. J Clin Endocrinol Metab. 1993 Oct;77(4):1028-32. doi: 10.1210/jcem.77.4.8408450. J Clin Endocrinol Metab. 1993. PMID: 8408450 Clinical Trial.

Welle S, Thornton C, Jozefowicz R, Statt M. Welle S, et al. Am J Physiol. 1993 May;264(5 Pt 1):E693-8. doi: 10.1152/ajpendo.1993.264.5.E693. Am J Physiol. 1993. PMID: 8498491

Tipton KD. Tipton KD. Curr Opin Clin Nutr Metab Care. 2001 Nov;4(6):493-8. doi: 10.1097/00075197-200111000-00005. Curr Opin Clin Nutr Metab Care. 2001. PMID: 11706282 Review.

Cited by

Aung SH, Abeyrathne EDNS, Hossain MA, Jung DY, Kim HC, Jo C, Nam KC. Aung SH, et al. Food Sci Anim Resour. 2023 Jul;43(4):639-658. doi: 10.5851/kosfa.2023.e25. Epub 2023 Jul 1. Food Sci Anim Resour. 2023. PMID: 37483995 Free PMC article.

Negrey JD, Deschner T, Langergraber KE. Negrey JD, et al. Anim Behav. 2023 Aug;202:99-109. doi: 10.1016/j.anbehav.2023.06.004. Epub 2023 Jul 4. Anim Behav. 2023. PMID: 37483564

Omi N, Yamamoto H, Yamaguchi T, Tsukiashi M, Yamamoto T, Tanaka R, Watanabe K, Maruki-Uchida H, Kawama T. Omi N, et al. Amino Acids. 2023 Jun;55(6):769-776. doi: 10.1007/s00726-023-03267-4. Epub 2023 May 8. Amino Acids. 2023. PMID: 37154870 Clinical Trial.

Lee J, Lee JH, Choo MS, Cho MC, Son H, Jeong H, Jeong JB, Yoo S. Lee J, et al. World J Urol. 2023 Jun;41(6):1621-1627. doi: 10.1007/s00345-023-04397-w. Epub 2023 Apr 8. World J Urol. 2023. PMID: 37031331

Miura S, Seko T, Himuro N, Koyama M, Saitoh S, Ohnishi H. Miura S, et al. J Foot Ankle Res. 2022 Oct 25;15(1):79. doi: 10.1186/s13047-022-00584-x. J Foot Ankle Res. 2022. PMID: 36280859 Free PMC article.

Cheap Canadian Pharma LLC. 775 Cambie St, Vancouver, BC, Canada. All Rights Reserved.