Is cialis affected by food

Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study.
Introduction: Sildenafil citrate has been used worldwide by men with erectile dysfunction. The prescribing information for sildenafil suggests ingestion 1 hour before sexual activity and also notes reduced maximum plasma concentration and delayed time to maximum concentration following ingestion with a high-fat meal. The clinical impact of coingestion of food and these factors has never been evaluated.
Aim: To determine, using a naturalistic study design, whether sildenafil taken 1 hour before or during a meal compared with usual ingestion 30-60 minutes before sexual activity affects efficacy or patient satisfaction.
Methods: After a 1-2-week washout, 48 men (29-79 years old), currently satisfied with sildenafil, followed each of four regimens: (A) sildenafil 1 hour before a meal and placebo 30-60 minutes before planned coitus vs. (B) placebo 1 hour before a meal and sildenafil 30-60 minutes before coitus; and (C) sildenafil during a meal and placebo 30-60 minutes before coitus vs. (D) placebo during a meal and sildenafil 30-60 minutes before coitus. Subjects were not instructed to change their regular dietary habits during the course of the study.
Main outcome measures: Change from baseline in the International Index of Erectile Function (IIEF) Erectile Function (EF) domain score, responses to Sexual Encounter Profile (SEP) questions 2 (erection sufficient for penetration) and 3 (erection sufficient to complete intercourse), and measures of patient preference and satisfaction.
Results: Mean changes in IIEF-EF domain scores were 11.4 for regimens A and B and 11.2 for C and D. Positive SEP2 responses were recorded for 93.9% and 91.8% of intercourse attempts in A and B and 91.4% and 92.6% in C and D. Corresponding results for SEP3 were 84.7% and 85.9%, and 83.4% and 87.5%, respectively. There were no significant differences between pairs of treatments on satisfaction. The time between sildenafil ingestion and intercourse attempt (0-0.5 to >10 hours) had no significant effect on responses to SEP2, but decreased responses to SEP3 from a maximum of 92.8% at 1.5-2 hours to 81.6% at more than 10 hours (P = 0.003).
Conclusions: No significant loss of efficacy occurs when sildenafil is taken shortly before or with a meal. The duration of action for sildenafil may exceed 10 hours.
Similar articles.
Rubio-Aurioles E, Porst H, Eardley I, Goldstein I. Rubio-Aurioles E, et al. J Sex Med. 2006 Nov;3(6):1037-1049. doi: 10.1111/j.1743-6109.2006.00310.x. J Sex Med. 2006. PMID: 17100937 Clinical Trial.
Broderick GA, Donatucci CF, Hatzichristou D, Torres LO, Valiquette L, Zhao Y, Loughney K, Sides GD, Ahuja S. Broderick GA, et al. J Sex Med. 2006 Jul;3(4):668-675. doi: 10.1111/j.1743-6109.2006.00273.x. J Sex Med. 2006. PMID: 16839323.
Ali ST. Ali ST. Pak J Pharm Sci. 2008 Jul;21(3):275-81. Pak J Pharm Sci. 2008. PMID: 18614424 Clinical Trial.
Montorsi F, Padma-Nathan H, Glina S. Montorsi F, et al. Urology. 2006 Sep;68(3 Suppl):26-37. doi: 10.1016/j.urology.2006.06.027. Urology. 2006. PMID: 17011373 Review.
Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Fink HA, et al. Arch Intern Med. 2002 Jun 24;162(12):1349-60. doi: 10.1001/archinte.162.12.1349. Arch Intern Med. 2002. PMID: 12076233 Review.
Cited by.
Badr-Eldin SM, Ahmed OA. Badr-Eldin SM, et al. Drug Des Devel Ther. 2016 Apr 5;10:1323-33. doi: 10.2147/DDDT.S103122. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27103786 Free PMC article.
Cho MC, Paick JS. Cho MC, et al. Ther Clin Risk Manag. 2014 May 14;10:341-54. doi: 10.2147/TCRM.S39727. eCollection 2014. Ther Clin Risk Manag. 2014. PMID: 24868160 Free PMC article. Review.
Sadovsky R, Brock GB, Gutkin SW, Sorsaburu S. Sadovsky R, et al. Int J Clin Pract. 2009 Aug;63(8):1214-30. doi: 10.1111/j.1742-1241.2009.02119.x. Int J Clin Pract. 2009. PMID: 19624789 Free PMC article. Review.
Publication types.