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pmid:21218651, controlled clinical trial, english abstract, yan-ping huang, fu-fu zheng, chun-hua deng, carbolines / administration & dosage, carbolines / therapeutic use*, drug administration schedule, erectile dysfunction / drug therapy*, erectile dysfunction / physiopathology, humans, male, penile erection, phosphodiesterase inhibitors / administration & dosage, phosphodiesterase inhibitors / therapeutic use*, tadalafil, treatment outcome, pubmed abstract, nih, nlm, ncbi, national institutes of health, national center for biotechnology information, national library of medicine, medline

[Daily medication of low-dose tadalafil improves endothelial function and erectile hardness of ED patients]
Objective: To evaluate the effects of daily medication of low-dose tadalafil on the improvement of endothelial function and erectile hardness in erectile dysfunction (ED) patients.
Methods: A total of 60 ED patients and 24 controls were treated with oral tadalafil at 5 mg/d for 6 – 8 weeks, and evaluated by international index of erectile function-5 (IIEF-5), erectile hardness grading scale (EHGS) and brachial artery flow-mediated dilation (FMD) test before and after the treatment. All the data obtained were analyzed by independent-sample and paired-sample t tests, respectively.
Conclusion: Long-term daily medication of low-dose tadalafil can significantly improve endothelial function and erectile hardness of ED patients.
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